My best advice is be aware of your girl and note anything out of the norm. Note how much water she is drinking, note her energy level, note how often she is urinating, note is she seems more restless or more "clingy" than is usual.
I just went through a closed pyo with one of my girls. The first indication that something was wrong happened about 7 weeks after her last heat cycle (she also short cycled coming in about every 3 to 4 months) and was when I noticed that she looked to be straining to urinate and squating for a long period of time. Temps were normal, food intake normal as was water consumption. The next day she followed me around and was on my heels the entire day. That evening I noted her going to the water bucket more often and drinking more than normal each time. I sensed she was "off" but she was still active, eating, no vaginal dishcarge and her temp was normal. Despite these things my instincts told me to have her seen by her vet. After some discussion (she did not present as a normal pyo) an ultrasound and bloodwork was done. White blood cells were very high and you could see her uterus appeared only slightly enlarged but visibly so. Off to surgery she went. Her uterus once removed weighed 7 pounds and looked like a pork roast!
If I had not been aware of changes in my girl, however subtle they were, she would not be sitting here at my side telling me to get off the computer and feed her breakfast. I think I will do just that and give her an extra treat just because.
