All I can say is WOW that is one heavy regiment of drugs.I understand we have been battling the rash ,bacteria hotspots ever since I got Kandy best we can get it is manageable.This last flare up the anti biotic did nothing until we added prednizone. A Nightmare.We need the weather to give us a cold winter here.That would help.Loki has a chronic skin infection issue, she has had one month of Keflex, one month of Cipro, and one month of Bactrim DS in succession....I swear the only time her skin was clear was when she took Flagyl for Giardiasis. Yes we have been to derm. Bumped up flea coverage(never seen a flea). No diet changes, just continued itchy, itchy, itchy. Bathe once a week with moisturizing Selsun Blue. Next step is ex diet of Royal Canine....Have spent over 800.00....still no definitive answer