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Developmental orthopedic disease in large-breed puppies
Rapid growth can rapidly lead to skeletal abnormalities. Here's how a careful look at a pup's nutrition can help.
Feb 4, 2013
By: Ed Kane, PhD
DVM NEWSMAGAZINE
In dogs, osteochondrosis is one of a diverse group of developmental orthopedic diseases (DODs) that occur in young growing animals, most commonly fast-growing large- and giant-breed dogs (e.g., rottweilers, golden retrievers, Great Danes, Newfoundlands, Saint Bernards).
Osteochondrosis in dogs is noted as a disruption in endochondrial ossification that results in a focal lesion.(1) It occurs in the physis or epiphysis of growth cartilage. When it occurs in physeal cartilage, it may cause growth abnormalities such as angular limb deformities in long bones. Osteochondrosis of the articular epiphyseal cartilage commonly occurs in the shoulder, stifle, hock and elbow.
Acute inflammatory joint disease may occur subsequent to osteochondrosis when the cartilage is disrupted and subchondral bone is exposed to synovial fluid. Inflammatory mediators and cartilage fragments are released into the joint, perpetuating the cycle of degenerative joint disease. The most critical period for the initiation of DOD occurs during early bone growth, before physeal closure. During this period (the first 12 months of life), the skeletal system is most susceptible to physical, nutritional and metabolic insults because of increased metabolic activity. Large and giant breeds are most susceptible because of their genetic potential for rapid growth. Familial history is an important predisposing factor for DOD in dogs.(1)
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The rest of the piece can be found at: http://veterinarynews.dvm360.com/dvm/article/articleDetail.jsp?id=804547&pageID=1
The dvm360.com website can be a bit finicky, if the link to the article doesn't work, try it again a bit later or search the main website for the title or author.
Rapid growth can rapidly lead to skeletal abnormalities. Here's how a careful look at a pup's nutrition can help.
Feb 4, 2013
By: Ed Kane, PhD
DVM NEWSMAGAZINE
In dogs, osteochondrosis is one of a diverse group of developmental orthopedic diseases (DODs) that occur in young growing animals, most commonly fast-growing large- and giant-breed dogs (e.g., rottweilers, golden retrievers, Great Danes, Newfoundlands, Saint Bernards).
Osteochondrosis in dogs is noted as a disruption in endochondrial ossification that results in a focal lesion.(1) It occurs in the physis or epiphysis of growth cartilage. When it occurs in physeal cartilage, it may cause growth abnormalities such as angular limb deformities in long bones. Osteochondrosis of the articular epiphyseal cartilage commonly occurs in the shoulder, stifle, hock and elbow.
Acute inflammatory joint disease may occur subsequent to osteochondrosis when the cartilage is disrupted and subchondral bone is exposed to synovial fluid. Inflammatory mediators and cartilage fragments are released into the joint, perpetuating the cycle of degenerative joint disease. The most critical period for the initiation of DOD occurs during early bone growth, before physeal closure. During this period (the first 12 months of life), the skeletal system is most susceptible to physical, nutritional and metabolic insults because of increased metabolic activity. Large and giant breeds are most susceptible because of their genetic potential for rapid growth. Familial history is an important predisposing factor for DOD in dogs.(1)
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The rest of the piece can be found at: http://veterinarynews.dvm360.com/dvm/article/articleDetail.jsp?id=804547&pageID=1
The dvm360.com website can be a bit finicky, if the link to the article doesn't work, try it again a bit later or search the main website for the title or author.
